British Air Force Typhoon FGR4s have operated alongside France's air force in a coordinated attack against an subterranean weapons facility in Syria operated by the IS group, as stated by the UK's MoD.
The location, located using surveillance, was assessed as containing munitions and bombs, the announcement noted, and was situated in mountains just above the historic site of Palmyra in the heart of Syria.
"Our fighter planes used precision-guided Paveway IV munitions to strike a series of access tunnels providing entry to the site... preliminary assessments are that the objective was successfully hit," the MoD said.
There was no sign of any civilian casualties in the operation late on Saturday and each participating jet returned safely, the defence officials confirmed.
The Typhoon FGR4s were assisted by a Voyager tanker plane.
Daesh - alternatively referred to as the so-called Islamic State - imposed jihadist rule over parts of Iraq and Syria before its territorial defeat in 2019.
"This operation underscores our UK leadership, and resolve to work closely with our allies, to stamp out any re-emergence of Daesh and their dangerous and violent ideologies in the Middle East," Britain's Defence Chief the Defence Secretary said.
RAF aircraft have carried out surveillance missions over Syria to "forestall any attempted comeback" of Islamic State following its routing at the Baghuz confrontation in 2019, the authorities noted.
"I must thank all the members of the UK armed forces participating in this mission for their skill and their valour," he added. "Including them were thousands of UK service members stationed over the festive period. This mission, to remove militants who endanger our safety, highlights how our armed forces are prepared to act, continuously, ensuring Britain's security within its borders and strong abroad."
In December, the United States armed forces executed what it termed a "major assault" against Islamic State objectives in the country, following an assault killed two US servicemembers and a civilian interpreter in the Palmyra area.
The U.N. says IS still maintains an estimated 5,000 to 7,000 combatants in Iraq and Syria.